This study examined the incidence, time course and predictive value of PGD after living-donor lobar lung transplantation (LDLLT).
METHODS We retrospectively investigated 75 patients (42 with LDLLT and 33 with CLT) who underwent lung transplantation from January 2008 to December 2013.
Patients were assigned PGD grades at six time points, as defined by the International Society for Heart and Lung Transplantation: immediately after final reperfusion, upon arrival at the intensive care unit (ICU), and 12, 24, 48 and 72 h after ICU admission. The majority of the LDLLT patients having severe PGD first developed PGD immediately after reperfusion, whereas more than half of the CLT patients first developed severe PGD upon ICU arrival or later.
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Severe PGD immediately after reperfusion was not associated with ventilator-free days during the first 28 postoperative days, time to discharge from ICU or hospital, or hospital mortality in CLT patients.
CONCLUSIONS Postoperative incidence of severe PGD was not significantly different between LDLLT and CLT patients.
In LDLLT patients, the onset of severe PGD tended to be earlier than that in CLT patients.
Severe PGD immediately after reperfusion was a significant predictor of postoperative morbidity and mortality in LDLLT patients but not in CLT patients.
Living-donor lobar lung transplantation (LDLLT) was first performed in the 1990s in response to a mismatch between the supply and demand for donor lungs from brain-dead donors .
We recently demonstrated that survival following LDLLT is similar to that observed for cadaveric lung transplantation (CLT), despite the worse preoperative condition of LDLLT patients, and the use of LDLLT as a viable option in patients who may not survive a long waiting period for cadaveric donors .In contrast, our analysis revealed that LDLLT patients require a greater duration of postoperative mechanical ventilation than CLT patients, probably due to the poorer preoperative condition of LDLLT patients.Sie suchen einen Brancheneintrag in Bielefeld-Brackwede zu Zahnarzt? Denn: Das Telefonbuch ist die Nummer 1, wenn es um Telefonnummern und Adressen geht.Millionen von Einträgen mit topaktuellen Kontaktdaten und vielen weiteren Informationen zeichnen Das Telefonbuch aus. In Bielefeld-Brackwede hat Das Telefonbuch 16 Zahnarzt-Adressen ausfindig gemacht. Lesen Sie auch die Bewertungen anderer Kunden, um den passenden Zahnarzt-Eintrag für Sie zu finden. Dann rufen Sie einfach an und fragen nach: Alle Telefonnummern sowie eine "Gratis anrufen"-Option finden Sie in den einzelnen Brackwedeer Zahnarzt-Adressen. OBJECTIVES Primary graft dysfunction (PGD) is a major cause of early morbidity and mortality after cadaveric lung transplantation (CLT).